A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

Leveraging Domain Knowledge to Learn Normative Behavior: A Bayesian Approach

This paper addresses the problem of norm adaptation using Bayesian reinforcement learning. We are concerned with the effectiveness of adding prior domain knowledge when facing environments with different settings as well as with the speed of adapting to a new environment. Individuals develop their normative framework via interaction with their surrounding environment (including other individual...

The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior.

The role of limbic-striato-pallidal circuitry in cocaine-induced reinstatement was evaluated. The transient inhibition of brain nuclei associated with motor systems [including the ventral tegmental area (VTA), dorsal prefrontal cortex (dPFC), core of the nucleus accumbens (NAcore), and ventral pallidum (VP)] prevented cocaine-induced reinstatement. However, only the VP proved to be necessary fo...

Cocaine addicts prone to cocaine-induced psychosis have lower body mass index than cocaine addicts resistant to cocaine-induced psychosis--Implications for the cocaine model of psychosis proneness.

BACKGROUND The specific pathogenesis of increased vulnerability to cocaine-induced paranoia/psychosis is unknown. Weight loss has been long observed in patients abusing stimulants (including cocaine and the amphetamines). In the current study, we compared Body Mass Index (calculated as weight in kilograms divided by the square of height in meters) in Cocaine-Induced Psychosis cases, referred to...

Biochemical and functional characterization of xenoreactive natural antibodies in hu-PBL-SCID mice.

An in vivo model system to understand the mechanism of xenograft rejection was established using human peripheral blood leukocyte-reconstituted SCID (hu-PBL-SCID) mice. Human xenoreactive natural antibodies (XNA), of IgM and IgG subtypes, capable of binding to pig aortic endothelial cells (PAEC) were detected in the sera of hu-PBL-SCID by ELISA and flowcytometric methods. Western blot analysis ...

Severe rhabdomyolysis induced by cocaine contaminated with caffeine: a case report